D0380
Nε-DNP-L-lysine hydrochloride
Synonym(s):
Nε-(2,4-Dinitrophenyl)-L-lysine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H16N4O6 · HCl
CAS Number:
Molecular Weight:
348.74
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Recommended Products
form
powder
storage temp.
−20°C
SMILES string
OC([C@@H](N)CCCCNC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1)=O.[H]Cl
InChI
1S/C12H16N4O6.ClH/c13-9(12(17)18)3-1-2-6-14-10-5-4-8(15(19)20)7-11(10)16(21)22;/h4-5,7,9,14H,1-3,6,13H2,(H,17,18);1H
InChI key
VDVXDUOPLKVMMM-UHFFFAOYSA-N
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Positive cooperativity in the hapten binding by the VL dimer of protein 315.
R Zidovetzki et al.
Molecular immunology, 18(6), 491-497 (1981-06-01)
N P Barney et al.
Current eye research, 7(9), 843-848 (1988-09-01)
Attenuation of the rat conjunctival response by repeated topical challenge with dinitrophenyl (DNP) hapten was demonstrated in our study. Adult rats were immunized by intraperitoneal injections of dinitrophenylated Ascaris suum extract (DNP-Asc) and alum. Serum levels of anti-DNP homocytotropic antibody
A Leonardi et al.
Ophthalmic research, 22(4), 209-219 (1990-01-01)
The ocular late-phase reaction (LPR) is a mast cell-dependent, delayed inflammatory reaction developing 4-12 h after the early-phase reaction (EPR). We developed a passive IgG1 antibody-dependent guinea pig model that clinically reproduced the biphasic reaction of ocular EPR and LPR.
R G Leslie
Molecular immunology, 22(5), 513-519 (1985-05-01)
The binding and release of soluble guinea pig IgG2-containing DNPBSA-anti-DNP complexes and antigen-free, covalently-linked anti-DNP IgG2 oligomers of similar size, by guinea pig peritoneal macrophages, has been examined in the absence and presence of monomeric IgG2, of unrelated antibody specificity
Effect of topical dexamethasone on the ocular allergic reaction in passively sensitized guinea pigs.
M C Mehta et al.
Ophthalmic research, 22(6), 351-358 (1990-01-01)
We examined the effect of extended topical pretreatment with dexamethasone (Dex) on the ocular allergic response in passively sensitized guinea pigs. The passive IgG1 antibody dependent guinea pig model used in these studies demonstrates both early- and late-phase ocular anaphylactic
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