C9377

Chenodeoxycholic acid

• Synonym(s): 3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodiol
• Empirical Formula (Hill Notation): C₂₄H₄₀O₄
• CAS Number: 474-25-9
• Molecular Weight: 392.57
• Beilstein/REAXYS Number: 3219887
• EC Number: 207-481-8
• MDL number: MFCD00064142
• UNSPSC Code: 12352106
• PubChem Substance ID: 24893153
• NACRES: NA.25

Properties

• description: anionic
• Quality Level: 200
• form: powder
• mol wt: 392.57 g/mol
• technique(s): protein quantification: suitable
• CMC: (3); 3
• mp: 165-167 °C (lit.)
• functional group: carboxylic acid
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
• InChI key: RUDATBOHQWOJDD-BSWAIDMHSA-N
• Gene Information: human ... CYP1A2(1544) , NR1H4(9971)

Description

General description

Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol.

Application

Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX). It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.

Biochem/physiol Actions

Bile Acid

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)