C5749

CGP 52608

≥98%, RORA activator, solid

• Synonym(s): 1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone, N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide
• Empirical Formula (Hill Notation): C₈H₁₂N₄OS₂
• CAS Number: 87958-67-6
• Molecular Weight: 244.34
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775098
• NACRES: NA.77
• MDL number: MFCD00942304
• Assay: ≥98%
• Form: solid

Properties

• Product Name: CGP 52608, ≥98%, solid
• Quality Segment: 100
• assay: ≥98%
• form: solid
• solubility: DMSO: >30 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: CNC(=S)N\N=C1/SCC(=O)N1CC=C
• InChI: 1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-
• InChI key: DDYJDIHOSRTMSE-FLIBITNWSA-N

Description

Application

CGP 52608 has been used as a RAR related orphan receptor α (RORα) synthetic agonist in THP-1 macrophages, in human monocyte cells THP1 and somatic testicular cells.

Biochem/physiol Actions

CGP 52608 is a thiazolidine derivative and an antiarthritic compound. It possesses immunostimulatory functionality and elicits antiproliferative effect in colon tumors. It is cytotoxic towards neural cell lines. CGP 52608 induces apoptosis in tumor and also favors G0-G1 cell cycle phase accumulation in neural cell lines.

CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA).

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable