Skip to Content
MilliporeSigma
All Photos(1)

Documents

C1605

Sigma-Aldrich

Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone

powder, ≥95%

Synonym(s):

Z-VDVAD-FMK

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
C32H46N5O11F
CAS Number:
210344-92-6
Molecular Weight:
695.73
MDL number:
MFCD03452881
UNSPSC Code:
12352209
PubChem Substance ID:
329774898
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

assay

≥95%

form

powder

color

white

solubility

DMSO: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)OC)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(C)C)C(=O)CF

InChI

1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21-,22-,26-,27-/m0/s1

InChI key

ANTIWMNLIROOQF-IREHUOSBSA-N

Gene Information

human ... CASP2(835)
mouse ... CASP2(12366)
rat ... CASP2(64314)

Amino Acid Sequence

Z-Val-Asp-OMe-Val-Ala-Asp-OMe-FMK

Biochem/physiol Actions

A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mingxing Tian et al.
Veterinary microbiology, 244, 108648-108648 (2020-05-14)
Brucella is a facultative intracellular bacterium, dividing into smooth- and rough-type Brucella. Smooth-type Brucella can dissociate into rough mutants with cytotoxicity for macrophages during infection, which is critical for Brucella egress and dissemination. However, the mechanism of cytotoxicity infected by
Wolfgang W Quitschke
PloS one, 7(6), e39568-e39568 (2012-07-07)
Curcumin preparations typically contain a mixture of polyphenols, collectively referred to as curcuminoids. In addition to the primary component curcumin, they also contain smaller amounts of the co-extracted derivatives demethoxycurcumin and bisdemethoxycurcumin. Curcuminoids can be differentially solubilized in serum, which
Jun Huang et al.
Journal of receptor and signal transduction research, 41(1), 6-14 (2020-07-02)
Acute myocardial infarction (AMI) represents a severe coronary heart disease with relatively high rate of mortality and usually can lead to the damage of the myocardial tissues. Reperfusion of the ischemic myocardial tissues can minimize AMI-induced damage. As far as
Alex Chernyavsky et al.
International immunopharmacology, 80, 106149-106149 (2020-01-21)
Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (AuAbs) binding to epidermal keratinocytes and inducing a devastating blistering disease affecting oral and/or esophageal surfaces and, sometimes, also the skin. Anti-keratinocyte AuAbs developed by the
Patrick Y Kim et al.
Apoptosis : an international journal on programmed cell death, 18(5), 639-651 (2013-02-14)
TRIM16 exhibits tumour suppressor functions by interacting with cytoplasmic vimentin and nuclear E2F1 proteins in neuroblastoma and squamous cell carcinoma cells, reducing cell migration and replication. Reduced TRIM16 expression in a range of human primary malignant tissues correlates with increased
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service