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B7563

BRD7389

≥98% (HPLC)

Synonym(s):

1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione

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Pack SizeSKUAvailabilityPrice
5 mg
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$186.00

About This Item

Empirical Formula (Hill Notation):
C24H18N2O2
CAS Number:
Molecular Weight:
366.41
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:

$186.00


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Quality Level

assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

[nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4

InChI

1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)

InChI key

XASCINRGTHLHGM-UHFFFAOYSA-N

Biochem/physiol Actions

BRD7389 is an inhibitor of the RSK kinase family.
BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.

Features and Benefits

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
N8914SML1863SML0376
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >20 mg/mL

solubility

DMSO: >20 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: >2 mg/mL (warmed)

color

orange

color

yellow

color

white to beige

color

light yellow to light brown


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Dana M Gwinn et al.
Cancer cell, 33(1), 91-107 (2018-01-10)
KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of



Global Trade Item Number

SKUGTIN
B7563-25MG04061832444604
B7563-5MG04061832444611

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