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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Check Cart for Availability | $186.00 |
About This Item
Empirical Formula (Hill Notation):
C24H18N2O2
CAS Number:
Molecular Weight:
366.41
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
orange
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
[nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4
InChI
1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)
InChI key
XASCINRGTHLHGM-UHFFFAOYSA-N
Biochem/physiol Actions
BRD7389 is an inhibitor of the RSK kinase family.
BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.
Features and Benefits
This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >20 mg/mL | solubility DMSO: >20 mg/mL | solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: >2 mg/mL (warmed) |
| color orange | color yellow | color white to beige | color light yellow to light brown |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dana M Gwinn et al.
Cancer cell, 33(1), 91-107 (2018-01-10)
KRAS is a regulator of the nutrient stress response in non-small-cell lung cancer (NSCLC). Induction of the ATF4 pathway during nutrient depletion requires AKT and NRF2 downstream of KRAS. The tumor suppressor KEAP1 strongly influences the outcome of activation of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B7563-25MG | 04061832444604 |
| B7563-5MG | 04061832444611 |



