B3811
B-9430 trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp3, Igl5, D-Igl7, Oic8]-Bradykinin trifluoroacetate salt
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About This Item
Empirical Formula (Hill Notation):
C64H95N19O13 · xC2HF3O2
CAS Number:
Molecular Weight:
1338.56 (free base basis)
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
under inert gas
solubility
H2O: ≥2 mg/mL
shipped in
wet ice
storage temp.
−20°C
Amino Acid Sequence
Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg
Biochem/physiol Actions
B-9430 was developed by Gera at the Stewart laboratory1 and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA2 = 8.6) and B1 receptors (pA2 = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.
Caution
Product is air and light sensitive. Store in the dark.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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