B2050

3-Bromo-7-nitroindazole

≥98% (TLC), powder

• Empirical Formula (Hill Notation): C₇H₄BrN₃O₂
• CAS Number: 74209-34-0
• Molecular Weight: 242.03
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278258
• MDL number: MFCD00159910

Properties

• assay: ≥98% (TLC)
• form: powder
• color: light yellow
• solubility: ethanol: 25 mg/mL, DMSO: soluble
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1cccc2c(Br)n[nH]c12
• InChI: 1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
• InChI key: NFSTZPMYAZRZPC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinson′s disease.

A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinson′s disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges