This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.
B150
BQ-123
≥99%, sodium salt, lyophilized powder
Synonym(s):
BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 mg | 14 left in stock | $513.00 |
About This Item
Empirical Formula (Hill Notation):
C31H41N6O7 Na
CAS Number:
Molecular Weight:
632.68
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
$513.00
14 left in stockDetails
Quality Level
assay
≥99%
form
lyophilized powder
storage temp.
−20°C
SMILES string
[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C
InChI
1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1
InChI key
VYCMAAOURFJIHD-PJNXIOHISA-N
Gene Information
human ... EDNRA(1909), EDNRB(1910)
rat ... Ednra(24326), Ednrb(50672)
1 of 1
This Item | |||
|---|---|---|---|
| form lyophilized powder | form solid | form powder | form (Powder or Lyophilized powder or film) |
| assay ≥99% | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. -10 to -25°C |
| Gene Information human ... EDNRA(1909), EDNRB(1910) | Gene Information human ... SSTR5(6755) | Gene Information - | Gene Information - |
Application
BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation.[1] It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.[2]
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Elín I Magnúsdóttir et al.
Journal of neuroinflammation, 17(1), 123-123 (2020-04-24)
Itch is an unpleasant sensation that can be debilitating, especially if it is chronic and of non-histaminergic origin, as treatment options are limited. Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that also has the ability to induce a burning, non-histaminergic
T D Warner et al.
British journal of pharmacology, 112(1), 207-213 (1994-05-01)
1. Endothelin-1 binds almost irreversibly to its receptors and causes prolonged vasoconstrictions. Here we have studied the reversal of established responses to ET-1 in vivo and in vitro by BQ-123, an ETA receptor-selective antagonist, and/or PD 145065, an ETA/ETB receptor
M Clozel et al.
Life sciences, 52(9), 825-834 (1993-01-01)
The aim of this study was to evaluate the role of endothelin and endothelin ETA receptor in the early cerebral vasoconstriction following subarachnoid hemorrhage (SAH) in the rat. SAH induced by injection of autologous blood in the cisterna magna reduced
Sarah Pisarcik et al.
American journal of physiology. Lung cellular and molecular physiology, 304(8), L549-L561 (2013-02-19)
Numerous cellular responses to hypoxia are mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 plays a central role in the pathogenesis of hypoxic pulmonary hypertension. Under certain conditions, HIF-1 may utilize feedforward mechanisms to amplify its activity. Since hypoxia
F Cosentino et al.
Journal of cardiovascular pharmacology, 22 Suppl 8, S332-S335 (1993-01-01)
The present study was designed to determine whether an endothelinA (ETA)-receptor antagonist BQ-123 (cyclo[Dtrp, Dasp, pro-D-Val-Leu]) or an ET-converting enzyme inhibitor phosphoramidon may prevent development of cerebral vasospasm after subarachnoid hemorrhage (SAH). A "double hemorrhage" canine model of the disease
Related Content
Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B150-1MG | 04061835435746 |
| B150-200UG | 04061833426128 |
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How should Product B150, BQ-123, be dissolved?
1 answer-
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Is Product B150 the free acid form of BQ-123, or is it a salt?
1 answer-
Product No. B150 is BQ123 sodium salt.
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What is the solution stability for Product B150, BQ-123?
1 answer-
We do not perform any solution stability studies on Product B150, BQ-123. The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned. Cardillo, C. et al., Hypertension, 33, 753-758 (1999). The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment. Bonvollet, S. et al., A.J.P. - Heart, 266 (4), H1327-H1331 (1994).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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