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B0935

Benazepril hydrochloride

≥98% (HPLC), solid

Synonym(s):

(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride

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$876.00

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$1,180.00

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About This Item

Empirical Formula (Hill Notation):
C24H28N2O5 · HCl
CAS Number:
86541-74-4
Molecular Weight:
460.95
NACRES:
NA.77
PubChem Substance ID:
24724409
UNSPSC Code:
12352200
MDL number:
MFCD00895734
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

H2O: >5 mg/mL

originator

Novartis

SMILES string

Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O

InChI

1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

InChI key

VPSRQEHTHIMDQM-FKLPMGAJSA-N

Gene Information

human ... ACE(1636)

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This Item
Q06321048619Y0001025
Benazepril hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B0935

Benazepril hydrochloride

Quinapril hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

Q0632

Quinapril hydrochloride

Benazepril hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1048619

Benazepril hydrochloride

Benazepril hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0001025

Benazepril hydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

solid

form

solid

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

solubility

H2O: >5 mg/mL

solubility

H2O: >10 mg/mL

solubility

-

solubility

-

originator

Novartis

originator

-

originator

-

originator

-

Gene Information

human ... ACE(1636)

Gene Information

human ... ACE(1636)

Gene Information

human ... ACE(1636)

Gene Information

human ... ACE(1636)

Biochem/physiol Actions

Benazepril is a long-acting angiotensin converting enzyme (ACE) inhibitor.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000496635
0000496635
0000083937
050M4715V
081M4738V

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Yoshihiko Kanno et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 25(6), 939-943 (2002-12-18)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder in humans. Hypertension is one of the major complications, and its control might affect the renal survival and disease mortality. Suitable antihypertensive agents have been discussed based
Daphne P Bicket
American family physician, 66(3), 461-468 (2002-08-17)
When first introduced in 1981, angiotensin-converting enzyme (ACE) inhibitors were indicated only for treatment of refractory hypertension. Since then, they have been shown to reduce morbidity or mortality in congestive heart failure, myocardial infarction, diabetes mellitus, chronic renal insufficiency, and
Nadine Bongaerts et al.
Nature communications, 13(1), 3905-3905 (2022-07-08)
Whole-cell screening for Mycobacterium tuberculosis (Mtb) inhibitors is complicated by the pathogen's slow growth and biocontainment requirements. Here we present a synthetic biology framework for assaying Mtb drug targets in engineered E. coli. We construct Target Essential Surrogate E. coli
Zeng-Mei An et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 35(3), 356-361 (2015-06-15)
Diabetic nephropathy (DN) is a common and serious clinical complication of diabetes and presently there are no effective ways to prevent its occurrence and progression. Recent studies show that pentoxifylline (PTX) can improve renal hemodynamics, reduce urinary protein excretion, and
A Salvetti et al.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 12(8), S91-S94 (1994-11-01)
SHORT- VERSUS LONG-ACTING ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS: Although ACE inhibitors are widely used in the treatment of hypertension, there are few data on trough:peak ratios and the data are contradictory. Part of the explanation for this lies in differences
View All Related Papers

Global Trade Item Number

SKUGTIN
B0935-250MG04061832895727
B0935-500MG04061832895734

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