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A9451

Aristolochic acid I sodium salt

powder, ≥97%

Synonym(s):

Aristolochic acid sodium salt

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50 MG

$155.00

250 MG

$548.00

$155.00

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About This Item

Empirical Formula (Hill Notation):
C17H10NNaO7
CAS Number:
10190-99-5
Molecular Weight:
363.25
NACRES:
NA.77
PubChem Substance ID:
24891454
UNSPSC Code:
12352202
EC Number:
233-463-4
MDL number:
MFCD00210760
Assay:
≥97%
Form:
powder
Solubility:
H2O: 50 mg/mL

Key Documents

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Quality Level

200

assay

≥97%

form

powder

solubility

H2O: 50 mg/mL

SMILES string

[Na+].COc1cccc2c1cc([N+]([O-])=O)c3c(cc4OCOc4c23)C([O-])=O

InChI

1S/C17H11NO7.Na/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13;/h2-6H,7H2,1H3,(H,19,20);/q;+1/p-1

InChI key

BQVOPWJSBBMGBR-UHFFFAOYSA-M

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This Item
O2751O0136C4945
Aristolochic acid I sodium salt powder, ≥97%

Sigma-Aldrich

A9451

Aristolochic acid I sodium salt

Sodium oxamate ≥98%

O2751

Sodium oxamate

Sodium oxalate BioXtra

Sigma-Aldrich

O0136

Sodium oxalate

Sodium cacodylate trihydrate BioXtra, ≥98%

Sigma-Aldrich

C4945

Sodium cacodylate trihydrate

form

powder

form

powder

form

powder

form

powder

assay

≥97%

assay

≥98%

assay

≥99.0% (titration)

assay

≥98%

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

-

solubility

H2O: 0.5 M, clear, colorless

Biochem/physiol Actions

Component of some Chinese herbal medicines, and responsible for their nephrotoxicity. Prodrug activated by reduction of the nitro group to an amine, which forms cytotoxic DNA adducts.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7498V
WXBF5849V
WXBF3627V
WXBF0804V
WXBD8085V

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Marika Manolopoulou et al.
American journal of physiology. Renal physiology, 316(5), F847-F855 (2019-02-14)
Flow cytometry studies on injured kidney tubules are complicated by the low yield of nucleated single cells. Furthermore, cell-specific responses such as cell cycle dynamics in vivo have conventionally relied on indirect immunohistochemistry and proximal tubule markers that may be
Huan Lu et al.
Theranostics, 10(10), 4323-4333 (2020-04-16)
Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC). East Asian populations, who have a high prevalence of UTUC, have an unusual genome-wide AA-induced
Khai Gene Leong et al.
Toxins, 13(10) (2021-10-23)
The plant-derived toxin, aristolochic acid (AA), is the cause of Chinese Herb Nephropathy and Balkan Nephropathy. Ingestion of high dose AA induces acute kidney injury, while chronic low dose ingestion leads to progressive kidney disease. Ingested AA is taken up
Xiaoyan Wang et al.
Cell death & disease, 11(8), 620-620 (2020-08-17)
Acute kidney injury (AKI) has a critical role in the development of chronic kidney disease (CKD). Building on our previous findings, we explored the role of miR-382 in facilitating the transition of AKI to CKD using the Aristolochic acid (AA)
Xiaoli Sun et al.
Cellular signalling, 62, 109331-109331 (2019-06-04)
Upon occurrence of kidney injury, tubular cells arrested in G2/M stage may promote interstitial fibroblast activation and kidney fibrosis through producing large amounts of pro-fibrotic cytokines. MTORC1 signaling is essential for controlling cell growth, however, the role and mechanisms for
View All Related Papers

Global Trade Item Number

SKUGTIN
A9451-50MG04061833616499
A9451-250MG04061833616482

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