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A8598

Sigma-Aldrich

Ancitabine hydrochloride

Synonym(s):

2,2′-Anhydro-(1-β-D-arabinofuranosyl)cytosine hydrochloride, Cyclo-C, Cyclocytidine

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About This Item

Empirical Formula (Hill Notation):
C9H11N3O4 · HCl
CAS Number:
10212-25-6
Molecular Weight:
261.66
EC Number:
233-515-6
MDL number:
MFCD00012636
UNSPSC Code:
12352200
PubChem Substance ID:
24278241
NACRES:
NA.77

form

powder

SMILES string

Cl[H].OC[C@H]1[C@H](O)O[C@@H]2[C@H]1OC3=NC(=N)C=C[N@@H]23

InChI

1S/C9H11N3O4.ClH/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8;/h1-2,4,6-8,10,13-14H,3H2;1H/t4-,6-,7+,8-;/m1./s1

InChI key

KZOWNALBTMILAP-JBMRGDGGSA-N

Application

Ancitabine hydrochloride is an antineoplastic agent for the treatment of lymphatic leukemia and sinus acceleration.

Biochem/physiol Actions

Antineoplastic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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Tyramine-like effect of cyclocytidine (2,2'-anhydro-1-β-arabinofuranosylcytosine hydrochloride), an antineoplastic agent
Oguro, K., Hashimoto, K.
The Journal of Experimental Medicine, 124, 83-90 (1978)
M Hewish et al.
British journal of cancer, 108(4), 983-992 (2013-01-31)
DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinical behaviour. To identify the therapeutic agents that might show selectivity for mismatch repair-deficient tumour cells, we screened a

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