A6226

AM251

>98% (HPLC), solid, cannabinoid receptor (CB1) antagonist

• Synonym(s): 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide
• Empirical Formula (Hill Notation): C₂₂H₂₁N₄OCl₂I
• CAS Number: 183232-66-8
• Molecular Weight: 555.24
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891069
• NACRES: NA.77
• MDL number: MFCD01861181
• Assay: >98% (HPLC)
• Form: solid

Properties

• Product Name: AM251, >98% (HPLC), solid
• Quality Segment: 100
• assay: >98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• originator: Sanofi Aventis
• SMILES string: Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCCCC4
• InChI: 1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
• InChI key: BUZAJRPLUGXRAB-UHFFFAOYSA-N
• Gene Information: mouse ... Cnr1(12801), Cnr2(12802) ; rat ... Cnr1(25248)

Description

Application

AM251, a CB₁ cannabinoid receptor antagonist, has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.

Biochem/physiol Actions

AM251 is a CB₁ cannabinoid receptor antagonist.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Salt content may vary.

Safety Information

• Hazard Codes: H413
• Precautionary Statements: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves