A5376

Acetylsalicylic acid

≥99.0%

• Synonym(s): 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin
• Linear Formula: 2-(CH₃CO₂)C₆H₄CO₂H
• CAS Number: 50-78-2
• Molecular Weight: 180.16
• Beilstein/REAXYS Number: 779271
• EC Number: 200-064-1
• MDL number: MFCD00002430
• UNSPSC Code: 12352106
• PubChem Substance ID: 24278218
• NACRES: NA.21

Properties

• biological source: synthetic
• Quality Level: 200
• assay: ≥99.0%
• form: powder
• color: white
• pKa (25 °C): 3.5
• mp: 134-136 °C (lit.)
• solubility: H₂O: 10 mg/mL at 37 °C(lit.); H₂O: 3 mg/mL at 25 °C(lit.); ethanol: 50 mg/mL; aqueous base: decomposes
• ε (extinction coefficient): 190 at 298 nm in aqueous base at 1 mM; 409 at 231 nm in aqueous base at 1 mM; 466 at 230 nm in aqueous acid at 1 mM; 68 at 278 nm in aqueous acid at 1 mM
• SMILES string: CC(=O)Oc1ccccc1C(O)=O
• InChI: 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
• InChI key: BSYNRYMUTXBXSQ-UHFFFAOYSA-N
• Gene Information: human ... ITGA2B(3674) , ITGB3(3690) , PTGS1(5742) , PTGS2(5743)

Description

General description

Acetylsalicylic acid is an organic compound commonly referred to as aspirin. It works by blocking the production of compounds in the body that cause pain, swelling, and fever. Acetylsalicylic acid also serves a vital function in preventing blood clots from forming in the arteries. In research, acetylsalicylic acid is studied for its role in oxidative stress, and in cancer research as a biomarker.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 482.0 °F
• flash_point_c: 250 °C
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves