A2504

6-Aminocaproic acid

≥99% (titration), powder

• Synonym(s): ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
• Linear Formula: H₂N(CH₂)₅CO₂H
• CAS Number: 60-32-2
• Molecular Weight: 131.17
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 24890662
• EC Number: 200-469-3
• Beilstein/REAXYS Number: 906872
• MDL number: MFCD00008238
• Assay: ≥99% (titration)
• Form: powder

Properties

• biological source: synthetic
• Quality Segment: 300
• assay: ≥99% (titration)
• form: powder
• technique(s): cell culture | mammalian: suitable
• color: white
• mp: 207-209 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• SMILES string: NCCCCCC(O)=O
• InChI: 1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
• InChI key: SLXKOJJOQWFEFD-UHFFFAOYSA-N
• Gene Information: human ... PLAT(5327), PLG(5340) ; rat ... Ppm1a(24666)

Description

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl₂, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): 404.6 - 408.2 °F
• Flash Point (°C): 207 - 209 °C
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves