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Aurothioglucose hydrate

Name: Aurothioglucose hydrate
Brand: SIGMA
Price: 222 USD
Availability: InStock

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

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Synonym(s):

Gold thioglucose, Solganal, Solganol

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Size/SKU	Availability	Price
5 mg	Estimated to ship onOctober 01, 2026fromMILWAUKEE	$222.00
25 mg	Estimated to ship onJanuary 13, 2027fromMILWAUKEE	$763.00

About This Item

Empirical Formula (Hill Notation):

C₆H₁₁AuO₅S · xH₂O

CAS Number:

12192-57-3

Molecular Weight:

392.18 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24724383

NACRES:

NA.77

EC Number:

235-365-7

Assay:

≥96% (titration)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Aurothioglucose hydrate, ≥96% (titration)

Quality Segment

100

assay

≥96% (titration)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

Description

Application

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC₅₀ approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Potent PKCι-Par6 interaction inhibitor

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	SML0178	O6004	N9412
Sigma-Aldrich A0606 Aurothioglucose hydrate	Sigma-Aldrich SML0178 ARL-17477 dihydrochloride hydrate	Sigma-Aldrich O6004 Octyl β-D-1-thioglucopyranoside	Sigma-Aldrich N9412 6β-Naltrexol hydrate
description ≥96% (titration)	description ≥98% (HPLC)	description ≥98.0% (GC)	description ≥96% (HPLC), powder
form powder	form powder	form crystalline	form powder
assay ≥96% (titration)	assay ≥98% (HPLC)	assay ≥98.0% (GC)	assay ≥96% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
storage condition desiccated	storage condition desiccated	storage condition -	storage condition -
solubility H₂O: 5 mg/mL, clear	solubility H₂O: ≥5 mg/mL	solubility -	solubility DMSO: ~12 mg/mL, H₂O: insoluble