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Sigma-Aldrich

Peptidoglycan from Staphylococcus aureus

cell wall component

Synonym(s):

Peptidoglycan from S. aureus

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About This Item

MDL number:
MFCD00212486
UNSPSC Code:
12352201
NACRES:
NA.32

form

lyophilized powder

solubility

soluble, hazy to turbid, colorless to faintly yellow

storage temp.

−20°C

Related Categories

Application

Peptidoglycan from Staphylococcus aureus has been used:
  • for the stimulation of lymphocytes: peptidoglycan activates the toll-like receptor 2 (TLR2), present in mammalian cells. It works as an antagonist of Poly (I:C)
  • for g-type lysozyme stimulation by intraperitoneally inoculating it into sole specimens
  • in phosphate buffer saline and injected into Labeo rohita fingerlings, to study its effect on nucleotide-binding oligomerization domain-2 (NOD-2) gene expression

Biochem/physiol Actions

The cell wall of gram positive bacteria is largely made up of peptidoglycan. It is composed of polysaccharide chains interlinked by peptide bridges. This peptidoglycan gives a certain rigidity to the cell wall and gives the cell mechanical strength. It is a surface molecule which is known to stimulate immune reactions including cytokine production to fever.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Major component of the cell wall in gram positive organisms. Consists of a glycan backbone with alternating β 1-4 linked residues of N-acetyl-D-glucosamine and muramic acid. The immunological activities of bacterial peptidoglycans; Peptidoglycan types of bacterial cell walls and their taxonomic implications; Antibody response to peptidoglycan during staphylococcal infections

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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ABC transporters involved in the biogenesis of the outer membrane in gram-negative bacteria
Narita S
Bioscience, Biotechnology, and Biochemistry, 75(6), 1044-1054 (2011)
Sara Abouelasrar Salama et al.
Mediators of inflammation, 2020, 6087109-6087109 (2020-07-23)
The serum amyloid A (SAA) gene family is highly conserved and encodes acute phase proteins that are upregulated in response to inflammatory triggers. Over the years, a considerable amount of literature has been published attributing a wide range of biological
Molecular characterization of nucleotide binding and oligomerization domain (NOD)-2, analysis of its inductive expression and down-stream signaling following ligands exposure and bacterial infection in rohu (Labeo rohita)
Swain B, et al.
Developmental and Comparative Immunology, 36(1), 93-103 (2012)
Peptidoglycan types of bacterial cell walls and their taxonomic implications.
K H Schleifer et al.
Bacteriological reviews, 36(4), 407-477 (1972-12-01)
A peptidoglycan recognition protein in innate immunity conserved from insects to humans
Kang D, et al.
Proceedings of the National Academy of Sciences of the USA, 95(17), 10078-10082 (1998)
View All Related Papers

Articles

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

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