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C3d Rabbit Polyclonal Antibody

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Pack Size	Availability	Price
1 mL	Check Cart for Availability	$216.00
0.1 mL	Check Cart for Availability	$242.00
0.5 mL	Check Cart for Availability	$561.00
7 mL	Check Cart for Availability	$600.00
1 mL	Check Cart for Availability	$837.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p)

Citations:

$216.00

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biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (403A-74), vial of 0.5 mL concentrate (403A-75), bottle of 1.0 mL predilute (403A-77), vial of 1.0 mL concentrate (403A-76), bottle of 7.0 mL predilute (403A-78)

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Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

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This Item	404A-1	404R-1	268A-1
Sigma-Aldrich 403A-7 C3d Rabbit Polyclonal Antibody	Sigma-Aldrich 404A-1 C4d Rabbit Polyclonal Antibody	Sigma-Aldrich 404R-1 C4d (SP91) Rabbit Monoclonal Antibody	Sigma-Aldrich 268A-1 IgD Rabbit Polyclonal Antibody
clone polyclonal	clone polyclonal	clone SP91, monoclonal	clone polyclonal
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
species reactivity human	species reactivity human	species reactivity human	species reactivity human
antibody form Ig fraction of antiserum	antibody form Ig fraction of antiserum	antibody form culture supernatant	antibody form Ig fraction of antiserum
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
manufacturer/tradename Cell Marque^®	manufacturer/tradename Cell Marque^®	manufacturer/tradename Cell Marque^®	manufacturer/tradename Cell Marque^®

General description

Complement component C3 is an integral part of the classical, lectin, and alternative complement pathways, and its cleavage products are involved in immune responses such as opsonization and cell lysis. C3d is a fragment of C3 that normally binds to pathogen surfaces to promote B-cell activation. However, deposition of C3d has also been observed in peritubular capillaries of transplanted kidneys undergoing acute allograft rejection.[1]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

RUO

Other Notes

C3d Positive Control Slides, Product No. 403S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Complement deposition in renal allografts with early malfunction.

G Eggertsen et al.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 109(12), 825-834 (2002-02-16)

Among patients with early severe impairment of renal allograft function we have previously identified a group displaying isolated deposition of complement factor C3 in glomeruli. Here we studied the pattern of complement deposition more extensively in allograft biopsies from five

C3d immunohistochemistry on formalin-fixed tissue is a valuable tool in the diagnosis of bullous pemphigoid of the skin.

Katrin Pfaltz et al.

Journal of cutaneous pathology, 37(6), 654-658 (2009-10-30)

Direct immunofluorescence (DIF) testing is an important procedure in the diagnosis of autoimmune bullous dermatoses. We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses. The immunohistochemical expression of C3d in bullous pemphigoid (BP) (n =

C3D deposition in peritubular capillaries indicates a variant of acute renal allograft rejection characterized by a worse clinical outcome.

Dirk R J Kuypers et al.

Transplantation, 76(1), 102-108 (2003-07-17)

C4d deposition in peritubular capillaries (PTCs) is a sign of humoral renal allograft rejection and an independent predictor of graft survival. Few investigators have focused on the meaning of capillary C3 deposition in rejecting grafts. Because C3 production can result

An experimental model of acute humoral rejection of renal allografts associated with concomitant cellular rejection.

Alice Bickerstaff et al.

The American journal of pathology, 173(2), 347-357 (2008-06-28)

Acute humoral rejection (AHR), which occurs in up to 8% of kidney transplant recipients, is a significant cause of renal allograft dysfunction and loss. More efficacious treatment modalities are needed to eliminate or curtail alloantibody production and its deleterious effects

Global Trade Item Number

SKU	GTIN
403A-74	0841683141235
403A-75	0841683141242
403A-76	0841683141259
403A-77	0841683141266
403A-78	0841683141273

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