RTC000093

1,4-Dioxane

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): 1,4-Dioxane, Diethylene oxide, Dioxane
• Linear Formula: C₄H₈O₂
• CAS Number: 123-91-1
• Molecular Weight: 88.11
• NACRES: NA.24
• UNSPSC Code: 41116107
• Beilstein/REAXYS Number: 102551
• MDL number: MFCD00006571

Properties

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to USP 1601521
• vapor density: 3 (vs air)
• vapor pressure: 27 mmHg ( 20 °C), 40 mmHg ( 25 °C)
• CofA: current certificate can be downloaded
• autoignition temp.: 356 °F
• expl. lim.: 22 %
• packaging: pkg of 20 mL
• refractive index: n20/D 1.422 (lit.)
• bp: 100-102 °C (lit.)
• mp: 10-12 °C (lit.)
• density: 1.034 g/mL at 25 °C (lit.)
• application(s): pharmaceutical small molecule
• storage temp.: 2-30°C
• SMILES string: C1COCCO1
• InChI: 1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
• InChI key: RYHBNJHYFVUHQT-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB9800 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS02,GHS08,GHS07
• signalword: Danger
• hcodes: H225,H319,H335,H350
• pcodes: P202 - P210 - P233 - P240 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Respiratory system
• supp_hazards: EUH019,EUH066
• Storage Class: 3 - Flammable liquids
• wgk: WGK 3
• flash_point_f: 53.6 °F
• flash_point_c: 12 °C