C1900000

Chlorpromazine hydrochloride

Name: Chlorpromazine hydrochloride
Brand: SIAL
Price: 254 USD

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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150 MG

$254.00

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉ClN₂S · HCl

CAS Number:

69-09-0

Molecular Weight:

355.33

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329774913

MDL number:

MFCD00012654

Beilstein/REAXYS Number:

3779989

Key Documents

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InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

chlorpromazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

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Pharmacopeia & Metrological Institute Standards

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Show Differences

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This Item	1125006	31679	BP856
C1900000 Chlorpromazine hydrochloride	USP 1125006 Chlorpromazine hydrochloride	Supelco 31679 Chlorpromazine hydrochloride	BP856 Chlorpromazine hydrochloride
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade analytical standard	grade pharmaceutical primary standard
manufacturer/tradename EDQM	manufacturer/tradename USP	manufacturer/tradename -	manufacturer/tradename BP
format neat	format neat	format neat	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule
API family chlorpromazine	API family chlorpromazine	API family -	API family chlorpromazine
Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)	Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)	Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)	Gene Information human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Y0000479

Chlorpromazine impurity D, European Pharmacopoeia (EP) Reference Standard

Y0000507

Chlorpromazine impurity A, European Pharmacopoeia (EP) Reference Standard

Y0000508

Chlorpromazine impurity E, European Pharmacopoeia (EP) Reference Standard

Y0001449

Chlorpromazine impurity F, European Pharmacopoeia (EP) Reference Standard

1125006

Chlorpromazine hydrochloride, United States Pharmacopeia (USP) Reference Standard

BP467

Chlorpromazine sulfoxide, British Pharmacopoeia (BP) Reference Standard

BP856

Chlorpromazine hydrochloride, British Pharmacopoeia (BP) Reference Standard

pictograms

GHS06

signalword

Danger

hcodes

H301,H330

pcodes

P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.

Cristiane Flora Villarreal et al.

Pharmacology, biochemistry, and behavior, 103(3), 678-683 (2012-11-28)

In recent years, evidence that sensitization of primary afferent nociceptors is an important event associated with chronic pain has been accumulating. The present study aimed to evaluate the participation of the prostaglandin and sympathetic components in the long-lasting sensitization of

In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures.

Jessica J W Broeders et al.

Toxicology in vitro : an international journal published in association with BIBRA, 27(3), 1057-1064 (2013-02-05)

The extrapolation of in vitro to in vivo toxicity data is a challenge. Differences in sensitivity between cell systems may be due to intrinsic properties of the cell but also because of differences in exposure. In this study, the cytotoxicity

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

Sébastien Anthérieu et al.

Hepatology (Baltimore, Md.), 57(4), 1518-1529 (2012-11-24)

Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells. Generation of reactive

Constitutively active 5-HT2/α1 receptors facilitate muscle spasms after human spinal cord injury.

Jessica M D'Amico et al.

Journal of neurophysiology, 109(6), 1473-1484 (2012-12-12)

In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents

Exposure of chlorpromazine to 266 nm laser beam generates new species with antibacterial properties: contributions to development of a new process for drug discovery.

Mihail Lucian Pascu et al.

PloS one, 8(2), e55767-e55767 (2013-02-14)

Phenothiazines when exposed to white light or to UV radiation undergo a variety of reactions that result in degradation of parental compound and formation of new species. This process is slow and may be sped up with exposure to high

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