69484

N-Methyl-N-trimethylsilylheptafluorobutyramide

derivatization grade (GC derivatization), LiChropur^™, ≥90% (GC)

• Synonym(s): N-Trimethylsilyl-N-methylheptafluorobutyramide, MSHFBA
• Linear Formula: CF₃CF₂CF₂CON(CH₃)Si(CH₃)₃
• CAS Number: 53296-64-3
• Molecular Weight: 299.26
• UNSPSC Code: 23151817
• NACRES: NA.22
• PubChem Substance ID: 329761696
• MDL number: MFCD00077822
• Beilstein/REAXYS Number: 6512894
• Assay: ≥90% (GC)
• Form: liquid

Properties

• grade: derivatization grade (GC derivatization)
• Quality Segment: 100
• assay: ≥90% (GC)
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• technique(s): HPLC: suitable, LC/MS: suitable, gas chromatography (GC): suitable, ion chromatography: suitable
• refractive index: n20/D 1.353
• bp: 148 °C (lit.)
• density: 1.254 g/mL at 25 °C (lit.)
• SMILES string: CN(C(=O)C(F)(F)C(F)(F)C(F)(F)F)[Si](C)(C)C
• InChI: 1S/C8H12F7NOSi/c1-16(18(2,3)4)5(17)6(9,10)7(11,12)8(13,14)15/h1-4H3
• InChI key: CMXKINNDZCNCEI-UHFFFAOYSA-N

Description

Application

• Simultaneous quantitation of cocaine, opiates, and their metabolites in human hair by positive ion chemical ionization gas chromatography-mass spectrometry: This study demonstrates the application of N-Methyl-N-trimethylsilylheptafluorobutyramide in forensic toxicology to analyze drug residues in human hair, providing a robust method for detecting such compounds at trace levels (Höld KM, Wilkins DG, Rollins DE, Joseph RE Jr, Cone EJ, 1998).


• Detection of stanozolol in hair by negative ion chemical ionization mass spectrometry: The research utilizes N-Methyl-N-trimethylsilylheptafluorobutyramide for the sensitive detection of stanozolol, a performance-enhancing steroid, in hair samples. This method is particularly useful in sports doping analyses to ensure fair play (Höld KM, Wilkins DG, Crouch DJ, Rollins DE, Maes RA, 1996).

Other Notes

N-methyl-N-trimethylsilylheptafluorobutyramide (MSHFBA) has been used in the silylation reaction during GC analysis of samples containing 1-monoolein, 2-monoolein, 1,2-diolein, 1,3-diolein, ethyl oleate, oleic acid and triolein.

Silylating agent for use in GC-analyses. It interferes least with flame-ionization detectors

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Warning
• Hazard Codes: H226,H315,H319,H335
• Precautionary Statements: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 91.4 °F - closed cup
• Flash Point (°C): 33 °C - closed cup
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter