32473

Metoclopramide

VETRANAL^®, analytical standard

• Synonym(s): 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide
• Empirical Formula (Hill Notation): C₁₄H₂₂ClN₃O₂
• CAS Number: 364-62-5
• Molecular Weight: 299.80
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329754232
• EC Number: 206-662-9
• Beilstein/REAXYS Number: 1884366
• MDL number: MFCD00211338

Properties

• grade: analytical standard
• Quality Segment: 100
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
• InChI: 1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
• InChI key: TTWJBBZEZQICBI-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), HTR3A(3359), HTR4(3360)

Description

General description

Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.

Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.

Application

Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:

• Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.

It may also be used as an internal standard for the determination of loratadine and desloratadine in:

• Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1