04420
Phosphinic acid
puriss., meets analytical specification of NF, 30-32%
Synonym(s):
Hypophosphorous acid
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About This Item
Linear Formula:
H3PO2
CAS Number:
Molecular Weight:
66.00
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
grade
puriss.
quality
meets analytical specification of NF
concentration
30-32%
impurities
≤0.002% heavy metals (as Pb)
density
1.206 g/mL at 20 °C (lit.)
anion traces
chloride (Cl-): ≤200 mg/kg
sulfate (SO42-): ≤200 mg/kg
cation traces
As: ≤1 mg/kg
Ca: ≤50 mg/kg
Cu: ≤5 mg/kg
Fe: ≤20 mg/kg
Na: ≤1000 mg/kg
SMILES string
O[PH2]=O
InChI
1S/H3O2P/c1-3-2/h3H2,(H,1,2)
InChI key
ACVYVLVWPXVTIT-UHFFFAOYSA-N
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General description
Phosphinic acid is a reagent containing P-H bond. Phosphinic acids (phosphinates) are the derivatives of phosphinic acid H2P(O)(OH). Biochemical, biological, and medical applications of phosphinic acid compounds have been evaluated. Natural products containing carbon-phosphorus bonds (phosphonic and phosphinic acids) have wide applications in medicine and agriculture. Phosphinic acids have been synthesized via Michael addition of phosphonous acids as well as esters to activated conjugated systems. Phosphinic acid (Hypophosphorous acid) is an effective radical reducing agent for organic halides, thionoesters and isocyanides.
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Preparation of phosphinic acids: Michael additions of phosphonous acids/esters to conjugated systems.
Thottathil JK, et al.
Tetrahedron Letters, 25(42), 4741-4744 (1984)
William W Metcalf et al.
Annual review of biochemistry, 78, 65-94 (2009-06-06)
Natural products containing carbon-phosphorus bonds (phosphonic and phosphinic acids) have found widespread use in medicine and agriculture. Recent years have seen a renewed interest in the biochemistry and biology of these compounds with the cloning of the biosynthetic gene clusters
Hypophosphorous acid and its salts: New reagents for radical chain deoxygenation, dehalogenation and deamination.
Barton DHR, et al.
Tetrahedron Letters, 33(39), 5709-5712 (1992)
M Collinsová et al.
Current medicinal chemistry, 7(6), 629-647 (2000-03-07)
This review summarizes our knowledge of biochemical, biological and medical applications and properties of phosphinic acid compounds. Phosphinic acid compounds (phosphinates) are derivatives of phosphinic acid H2P(O)(OH). The major attention of this article is focused on applications of phosphinates of
The invention of radical reactions. Part 32. Radical deoxygenations, dehalogenations, and deaminations with dialkyl phosphites and hypophosphorous acid as hydrogen sources.
Barton DHR, et al.
The Journal of Organic Chemistry, 58(24), 6838-6842 (1993)
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