MABC200

Anti-APC Antibody, clone CC-1

clone CC-1, from mouse

• Synonym(s): Adenomatous polyposis coli protein, APC, Deleted in polyposis 2.5
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: CC-1, monoclonal
• Application: IHC
• Citations: 31

Properties

• biological source: mouse
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: CC-1, monoclonal
• species reactivity: human
• technique(s): immunohistochemistry: suitable
• isotype: IgG2bκ
• NCBI accession no.: NP_000029
• UniProt accession no.: P25054
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... APC(324)

Description

General description

311 kDa calculated

Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.

Immunogen

Recombinant protein corresponding to human APC.

Application

Anti-APC Antibody, clone CC-1 detects levels of APC proteins & has been published & validated for use in IHC.

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in human brain tissue containing multiple schlerosis lesions (Saikali, P. et al. (2007). J Neurosci. 27(5):1220-1228.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).

Physical form

Format: Purified

Analysis Note

Immunohistochemistry Analysis: A 1:5 dilution from a representative lot detected APC in human colorectal cancer tissue, human smooth muscle tissue, and human colon tissue.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable