EX0245

Ethyl acetate

HPLC, Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs

• Synonym(s): Acetic Acid Ethyl Ester, EtOAc
• Linear Formula: CH₃COOC₂H₅
• CAS Number: 141-78-6
• Molecular Weight: 88.11
• EC Index Number: 205-500-4
• UNSPSC Code: 12352108
• Beilstein/REAXYS Number: 506104
• MDL number: MFCD00009171
• Assay: ≥99.8% (GC)
• Technique(s): HPLC: suitable
• Bp: 76.5-77.5 °C (lit.)
• Vapor pressure: 73 mmHg ( 20 °C)

Properties

• agency: meets USP/NF
• Quality Segment: 100
• vapor density: 3 (20 °C, vs air)
• vapor pressure: 73 mmHg ( 20 °C)
• assay: ≥99.8% (GC)
• form: liquid
• autoignition temp.: 801 °F
• expl. lim.: 2.2-11.5 %, 38 °F
• technique(s): HPLC: suitable
• impurities: ≤0.0009 meq/g Titrable acid, ≤0.05% Water (H₂O)
• evapn. residue: ≤5 ppm
• color: APHA: ≤10
• refractive index: n20/D 1.3720 (lit.)
• bp: 76.5-77.5 °C (lit.)
• mp: −84 °C (lit.)
• transition temp: flash point -4 °C
• density: 0.902 g/mL at 25 °C (lit.)
• UV cutoff: ≤255 nm
• UV absorption: λ: 255 nm A_max: ≤1.00, λ: 257 nm A_max: ≤0.50, λ: 263 nm A_max: ≤0.10, λ: 275 nm A_max: ≤0.05, λ: 300-400 nm A_max: ≤0.01
• format: neat
• shipped in: ambient
• storage temp.: room temp
• SMILES string: CCOC(C)=O
• InChI: 1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
• InChI key: XEKOWRVHYACXOJ-UHFFFAOYSA-N

Description

General description

Ethyl acetate is a volatile, moderately polar solvent widely used in analytical chromatography. Its high purity, low UV absorbance, and compatibility with aqueous and organic phases make it suitable for HPLC, GC, and pharmaceutical testing. Meeting ACS and USP/NF specifications ensures its reliability in regulated environments and compendial methods.

Application

EX0245P-1 is packaged in poly coated glass bottles
EX0245-NP10 is sold as 2 x 10 L

Ethyl acetate can be used as a:

• Mobile phase component in normal-phase HPLC for separating non-polar and moderately polar compounds, especially in pharmaceutical and food analysis.
• Sample preparation solvent for volatile and semi-volatile organic compounds due to its rapid evaporation and clean baseline characteristics.

Packaging

M-Bottle for Solvents
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Preparation Note

Product filtered through a 0.2 μm filter

Analysis Note

AppearanceClear liquid, free from particulatesAssay (GC)99.8% minColor (APHA)10 maxEvaporation residue5ppm maxFiltered through 0.2 µm filterTo pass testFormLiquidInfrared SpectrumConforms to standardSubstances darkened by sulfuric acidTo pass testTitrable acid0.0009meq/g maxUV Abs. at 255 nm1.00AU maxUV Abs. at 257 nm0.50AU maxUV Abs. at 263 nm0.10AU maxUV Abs. at 275 nm0.05AU maxUV Abs. at 300 - 4000.01AU maxUV Cut-off255nm maxWater (H2O)0.05% max

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Codes: H225,H319,H336
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Central nervous system
• supp_hazards: EUH066
• Storage Class: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point (°F): 24.8 °F - closed cup
• Flash Point (°C): -4 °C - closed cup