ABN415

Anti-TRAPPC1 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): TRAPPC-1, Trafficking protein particle complex subunit 1, BET5 homolog, Multiple myeloma protein 2, MUM-2, MUM2
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: -

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human
• species reactivity (predicted by homology): monkey (based on 100% sequence homology)
• technique(s): immunohistochemistry: suitable, western blot: suitable
• NCBI accession no.: NP_001160093
• UniProt accession no.: Q9Y5R8
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... TRAPPC1(58485)

Description

General description

TRAPPC1 is one part of a larger protein complex called the TRAPP (transport protein particle) complex vital to Golgi function and transport. TRAPPC1 is localized to the Golgi and endoplasmic reticulum. Vesicle-mediated transport is a process carried out by virtually all cells and is required for the proper targeting and secretion of proteins. As such, there are numerous proteins involved to ensure that the proteins are properly transported, targeted, tethered, and localized. The TRAPP complex is just one such complex but it is one of the most studied. Mutations in TRAPPC proteins can lead to serious disorders including muscular dystrophy and myopathy such as that seen with mutations associated with TRAPPC11 (a related gene to TRAPPC1).

~19 kDa observed. The endogenous band appears at ~31kDa (mouse brain) while the transfected band appears at ~19kDa

Immunogen

Epitope: Near C-terminus

KLH-conjugated linear peptide corresponding to the Near C-terminus of Human TRAPPC1.

Application

Research Category
Neuroscience

Neuroscience

Research Sub Category
Ion Channels & Transporters

Neurotransmitters & Receptors

This Anti-TRAPPC1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of TRAPPC1.

Western Blotting Analysis: 0.25 µg/mL from a representative lot detected TRAPPC1 in 5 µg of mouse brain tissue lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAPPC1 in human cerebral cortex, cerebellum, and kidney.

Physical form

Antigen Affinity Purified

Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in TRAPPC1 transfected HEK293T cell lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected TRAPPC1 in 5 µg of TRAPPC1 transfected HEK293T cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable