420143

JNK3 Inhibitor XII, SR-3576

The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): JNK3 Inhibitor XII, SR-3576, 3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
• Empirical Formula (Hill Notation): C₂₇H₂₇N₅O₅
• CAS Number: 1164153-22-3
• Molecular Weight: 501.53
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD18632556
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [n]3(ncc(c3)NC(=O)Nc4cc(ccc4)C)c1cc(ccc1)C(=O)Nc2cc(c(c(c2)OC)OC)OC
• InChI: 1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
• InChI key: MTFAYLZZDJGFGV-UHFFFAOYSA-N

Description

General description

A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC₅₀ = 7 nM), inhibiting JNK1 only at much higher concentrations (IC₅₀ = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC₅₀ = 1.3 µM).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kamenecka, T., et al. 2009. J. Biol. Chem.284, 12853.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable