391333

HEPES sodium salt

ULTROL^® Grade, ≥99% dry basis (titration), zwitterionic N-substituted aminosulfonic acid buffer

• Synonym(s): HEPES, Sodium Salt, ULTROL^® Grade, N-2-Hydroxyethylpiperazine-Nʹ-2-ethanesulfonic Acid, Na
• Empirical Formula (Hill Notation): C₈H₁₇N₂O₄S · Na
• CAS Number: 75277-39-3
• Molecular Weight: 260.29
• MDL number: MFCD00036463
• UNSPSC Code: 12161704
• NACRES: NA.25

Properties

• Quality Segment: 100
• assay: ≥99% dry basis (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• pKa (20 °C): 7.6
• solubility: water: 1.0 M
• anion traces: chloride (Cl^-): <0.01%, sulfate (SO₄^2-): <0.05%
• cation traces: heavy metals: <1 ppm
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: [Na+].[S](=O)(=O)([O-])CCN1CCN(CC1)CCO
• InChI: 1S/C8H18N2O4S.Na/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;/h11H,1-8H2,(H,12,13,14);/q;+1/p-1
• InChI key: RDZTWEVXRGYCFV-UHFFFAOYSA-M

Description

General description

A zwitterionic N-substituted aminosulfonic acid buffer(Absorbance: <0.10 at 260 nm, 1.0 mM, H₂O). Active in the pH range of 6.0 to 8.5. Has a pK_a of 7.6 at 20°C.

Absorbance (1.0 mM, H₂O, 260 nm):<0.10.

Application

• 3,6-O-[N-(2-Aminoethyl)-acetamide-yl]-chitosan exerts antibacterial activity by a membrane damage mechanism.: This study explores the antibacterial mechanisms of a chitosan derivative, which could be related to the buffering capabilities of HEPES in maintaining the stability and exposure of functional groups necessary for antibacterial activity (Yan et al., 2016).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable