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370656

Guanosine 3′,5′-cyclic Monophosphate, Sodium Salt

Important intracellular second messenger implicated in the action of nitric oxide in many cell types.

Synonym(s):

Guanosine 3′,5′-cyclic Monophosphate, Sodium Salt, Cyclic GMP, G-3,5-MP, cGMP, Na

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Size/SKUAvailabilityPrice
50 mg
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$91.20

About This Item

Empirical Formula (Hill Notation):
C10H11N5O7P · Na
CAS Number:
Molecular Weight:
367.19
UNSPSC Code:
41106305
NACRES:
NA.77
MDL number:
Assay:
>98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)

$91.20


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Quality Segment

description

Merck USA index - 14, 2709

assay

>98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na+].[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4nc(nc(c4nc3)[O-])N)CO1)O

InChI

1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI key

KMPIYXNEROUNOG-GWTDSMLYSA-M

General description

An important intracellular second messenger implicated in mediating the action of nitric oxide in many cell types. Found to activate protein kinase G. Suppresses apoptosis in rat ovarian follicles.
Important intracellular second messenger implicated in the action of nitric oxide in many cell types. Activates protein kinase G. Suppresses apoptosis in rat ovarian follicles.

Biochem/physiol Actions

Primary Target
Activates protein kinase G
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Chun, S.Y., et al. 1995. Endocrinology136, 3120.
Kaupp, U.B., and Koch, K.W. 1992. Annu. Rev. Physiol.54, 153.
Goldberg, N.D., and Haddox, M.K. 1977. Annu. Rev. Biochem. 46, 823.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
203820203800G6129
description

Important intracellular second messenger implicated in the action of nitric oxide in many cell types.

description

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.

description

Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP.

description

≥99% (HPLC), powder

assay

>98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (HPLC)

form

solid

form

solid

form

solid

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 1 mg/mL

solubility

water: 200 mg/mL

solubility

water: soluble

solubility

H2O: 50 mg/mL


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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