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368050

Granzyme B Inhibitor I

≥95% (HPLC), solid, Granzyme B inhibitor, Calbiochem®

Synonym(s):

Granzyme B Inhibitor I, Z-AAD-CMK

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Size/SKUAvailabilityPrice
1 mg
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$124.00

About This Item

Empirical Formula (Hill Notation):
C19H24ClN3O7
Molecular Weight:
441.86
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated

$124.00

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Product Name

Granzyme B Inhibitor I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
A weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Granzyme B
Product does not compete with ATP.
Reversible: no
Target IC50: 300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Z-Ala-Ala-Asp-CH₂Cl
Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry30, 2217.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item
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Granzyme B Inhibitor I The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

368050

Granzyme B Inhibitor I

Granzyme B Inhibitor II The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

368055

Granzyme B Inhibitor II

Granzyme B Inhibitor IV The Granzyme B Inhibitor IV controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

368056

Granzyme B Inhibitor IV

Caspase-8 Inhibitor I, Cell-Permeable The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

218773

Caspase-8 Inhibitor I, Cell-Permeable

form

solid

form

lyophilized solid

form

solid

form

lyophilized solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze, desiccated

storage condition

OK to freeze

storage condition

OK to freeze

storage condition

OK to freeze

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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