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344935

Furin Substrate, Fluorogenic

A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹).

Synonym(s):

Furin Substrate, Fluorogenic

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Size/SKUAvailabilityPrice
5 mg
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$383.00

About This Item

Empirical Formula (Hill Notation):
C37H57N13O9
Molecular Weight:
827.93
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

$383.00


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Quality Segment

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 10 mg/mL, DMSO: soluble

fluorescence

λex 360 - 380 nm, λem 430-460 nm

shipped in

ambient

storage temp.

−20°C

General description

A fluorogenic substrate for furin (kcat/Km ~2 X 104 M-1 s-1), a mammalian homolog of the yeast Kex2 endoprotease. Also serves as a substrate for related protein, prohormone convertase 2 (PC2) (kcat/Km ~6 X 103 M-1 s-1). Excitation max: ~360-380 nm; emission max: ~430-460 nm).
A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 104 s-1M-1).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Fluorogenic substrate for furin
Product does not compete with ATP.
Reversible: no
kcat/Km ~ 2 x 104 s-1M-1 for furin

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lamango, N.S., et al. 1996. Arch. Biochem. Biophys.330, 238.
Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
Pyr-Arg-Thr-Lys-Arg-AMC

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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420314444212208748
description

A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹).

description

Sensitive fluorogenic substrate for kallikreins.

description

A quenched fluorescence substrate for MMP-2 (gelatinase A; kcat/Km = 3.97 x 10⁵ M⁻¹s⁻¹).

description

An internally quenched fluorogenic substrate peptide derived from the calpain-1 cleavage site of α-spectrin.

form

solid

form

lyophilized

form

lyophilized solid

form

lyophilized solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: soluble, water: 10 mg/mL

solubility

DMSO: 5 mg/mL, 5% acetic acid: 1 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 1 mg/mL


Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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