203995
N-tert-Butyl-α-phenylnitrone
Most commonly-used free radical trap.
Synonym(s):
N-tert-Butyl-α-phenylnitrone, PBN
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About This Item
Empirical Formula (Hill Notation):
C11H15NO
CAS Number:
Molecular Weight:
177.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (GC)
Form:
solid
Storage condition:
OK to freeze
Quality Segment
assay
≥98% (GC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 10 mg/mL, water: 20 mg/mL, chloroform: 50 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
[N+](=Cc1ccccc1)([O-])C(C)(C)C
InChI
1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3
InChI key
IYSYLWYGCWTJSG-UHFFFAOYSA-N
General description
Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Biochem/physiol Actions
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Free radical trap
Free radical trap
Preparation Note
Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
Other Notes
Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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