197900

BEC, Hydrochloride

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5).

• Synonym(s): BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)
• Empirical Formula (Hill Notation): C₅H₁₂BNO₄S · xHCl
• Molecular Weight: 193.03 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥97% (NMR)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Properties

• Quality Segment: 100
• assay: ≥97% (NMR)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K_i = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.

Biochem/physiol Actions

Cell permeable: no

Primary Target
arginase 1, arginase 2

Product does not compete with ATP.

Reversible: no

Target K_i: 310 nM for human recombinant type II arginase, pH 7.5

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.

Other Notes

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3