189480-M

Autocamtide-2 Related Inhibitory Peptide

The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Autocamtide-2 Related Inhibitory Peptide, AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
• Empirical Formula (Hill Notation): C₆₄H₁₁₆N₂₂O₁₉
• Molecular Weight: 1497.74
• UNSPSC Code: 12352202

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• storage temp.: −20°C

Description

General description

Non-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC₅₀ = 40 nM) and is 50 and 500 times more potent than Ala²⁸⁶-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.

Non-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC₅₀ = 40 nM). It is about 50 times more potent than [Ala²⁸⁶]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca²⁺-induced insulin secretion from electropermeabilized islets.

Biochem/physiol Actions

Target IC₅₀: 40 nM against calmodulin-dependent protein kinase II

Warning

Toxicity: Standard Handling (A)

Sequence

H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH

Other Notes

Bhat, H.S., et al. 2000. Biochem. Pharmacol.60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable