Skip to Content

Legal compliance reminder: purchasers must obtain all necessary licenses and comply with applicable laws (see General Terms & Conditions of Sale). We reserve the right to request additional information.

MilliporeSigma

Key Documents

View All Documentation

Skip To

124013

Akt Inhibitor VI, Akt-in

The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Promotion Available

Synonym(s):

Akt Inhibitor VI, Akt-in, TCL110-24, H-AVTDHPDRLWAWEKF-OH

Sign In to View Organizational & Contract Pricing.

Spend $500 — Save 5%; Spend $800 — Save 10%; Spend $1,600 — Save 22%*

Sign in to check eligibility. Shop Products

Select a Size

Change View
Size/SKUAvailabilityPrice
2 mg
Check Cart for Availability
$252.00

About This Item

Empirical Formula (Hill Notation):
C88H123N23O23
Molecular Weight:
1871.06
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated (hygroscopic)

$252.00

Save Up To 22%

Check Cart for Availability
​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.

Biochem/physiol Actions

Cell permeable: no
Kd ~18 µM in binding to Akt-PH domain
Primary Target
Akt
Product does not compete with ATP.
Reversible: yes

Packaging

Packaged under inert gas

Physical form

Supplied as an acetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Hiromura, M., et al. 2004. J. Biol. Chem.279, 53407.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
328000420116124017
Akt Inhibitor VI, Akt-in The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

124013

Akt Inhibitor VI, Akt-in

ERK Activation Inhibitor Peptide I, Cell-Permeable The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

328000

ERK Activation Inhibitor Peptide I, Cell-Permeable

JNK Inhibitor I, (L)-Form, Cell-Permeable The JNK Inhibitor I, (L)-Form, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420116

JNK Inhibitor I, (L)-Form, Cell-Permeable

Akt Inhibitor VIII, Akti-1/2 InSolution, ≥95%, Isozyme-Selective

Sigma-Aldrich

124017

Akt Inhibitor VIII, Akti-1/2

description

The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

The JNK Inhibitor I, (L)-Form, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

InSolution, ≥95%, Isozyme-Selective

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

form

lyophilized solid

form

lyophilized solid

form

lyophilized solid

form

liquid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

solubility

water: 1 mg/mL

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

solubility

water: 2 mg/mL

solubility

-

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
2829738

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters