1.04239

Glutardialdehyde solution 25%

for electron microscopy

• Synonym(s): Glutaraldehyde solution, Glutaric dialdehyde solution, Pentane-1,5-dial
• Linear Formula: OHC(CH₂)₃CHO
• CAS Number: 111-30-8
• Molecular Weight: 100.12
• Beilstein/REAXYS Number: 605390
• MDL number: MFCD00007025
• UNSPSC Code: 12352114
• NACRES: NA.21

Properties

• vapor pressure: 0.27 hPa ( 20 °C)
• Quality Level: 200
• form: liquid
• concentration: 23.5-26.5% (alkalimetric)
• technique(s): electron microscopy: suitable
• color: colorless
• pH: >3.0 (20 °C in H₂O)
• bp: 100.5 °C/1013 hPa
• mp: -6 °C
• density: 1.06 g/cm³ at 20 °C
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: 2-8°C
• SMILES string: [H]C(CCCC([H])=O)=O
• InChI: 1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
• InChI key: SXRSQZLOMIGNAQ-UHFFFAOYSA-N

Description

General description

Glutardialdehyde solution 25% - for electron microscopy, is a fixing agent for specimens destined for morphological and enzyme histochemical analysis. The 25% Glutardialdehyde solution is used for the fixation of specimen of human origin for semi-thin cuttings and electron microscopy. It is diluted with phosphate buffer(Potassium dihydrogen phosphate for analysis EMSURE^® ISO (Product number 1.04873) or di-Sodium hydrogen phosphate anhydrous for analysis EMSURE^® ACS,Reag. Ph Eur (Product number 1.06586)
to achieve the corresponding working concentration. Alternatively, especially sensitive material used for enzyme histochemistry, will be fixed with glutardialdehyde according to P.J. Anderson, purified and filled into ampoules under nitrogen (Product number 1.12179). Sensitive enzymes e.g. endogenous peroxidase can often only be visualized in this way. It is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

Analysis Note

Assay (alkalimetric): 23.5 - 26.5 %
pH-value: ≥ 3.0
Density (d 20 °C/ 4 °C): 1.060 - 1.065
Absorbance A (235 nm; 1:200 deluted with water; 1 cm): ≤ 0.3

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05,GHS07,GHS08,GHS09
• signalword: Danger
• hcodes: H302 + H332 - H314 - H317 - H334 - H335 - H410
• pcodes: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• supp_hazards: EUH071
• Storage Class: 8A - Combustible, corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable