06-272
Anti-JAK1 Antibody
serum, Upstate®
Synonym(s):
Anti-AIIDE, Anti-JAK1B, Anti-JTK3
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rabbit, hamster, mouse, human, rat
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... JAK1(3716)
Specificity
JAK1
Immunogen
HPLC-purified (>98%) peptide corresponding to 21 amino acids of human JAK1 (KTLIEKERFYESRCRPVTPS-C)
Application
Anti-JAK1 Antibody detects level of JAK1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Immunological Signaling
Quality
routinely evaluated by immunoblot on RIPA lysate from mouse CTLL lymphocytes, TF-1 erythroleukemic cells or mouse thymus
Target description
130 kDa
Physical form
Antiserum
whole rabbit antiserum containing 0.05% sodium azide
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Intermediate affinity interleukin-2 receptor mediates survival via a phosphatidylinositol 3-kinase-dependent pathway
Gonzalez-Garcia, A., et al
The Journal of Biological Chemistry, 272, 10220-10226 (1997)
C F Lai et al.
The Journal of biological chemistry, 274(12), 7793-7802 (1999-03-13)
Interleukin (IL)-6 is a major regulator of hepatic acute-phase plasma protein (APP) genes. The membrane-proximal 133-amino acid cytoplasmic domain of glycoprotein (gp) 130, containing one copy of the Box3 motif, is sufficient to transmit a productive signal to endogenous APP
Lixin Rui et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7260-E7267 (2016-11-02)
Janus kinases (JAKs) classically signal by activating STAT transcription factors but can also regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41 (H3Y41-P). In diffuse large B-cell lymphomas (DLBCLs), JAK signaling is a feature of the activated B-cell
Svantje Sobotta et al.
Frontiers in physiology, 8, 775-775 (2017-10-25)
IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated with multiple pathological conditions. In hepatocytes, IL-6 activates JAK1-STAT3 signaling
Fen Zhu et al.
Molecular cancer research : MCR, 15(3), 348-357 (2016-12-30)
JAKs are non-receptor tyrosine kinases that are generally found in association with cytokine receptors. In the canonical pathway, roles of JAKs have well been established in activating STATs in response to cytokine stimulation to modulate gene transcription. In contrast, a
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service