760943
Poly(ethylene glycol), 8 acetylene dendron, generation 2
average Mn 21,000
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
description
acetylene surface groups
form
solid
mol wt
PEG average Mn 20,000 (n~450; esterified with 8 acetylene groups)
Mn 16,000-21,000 (by NMR)
average Mn 21,000
feature
generation 2
no. Surface Groups
8
transition temp
Tm 56-60 °C
Mw/Mn
≤1.4
functional group
alkyne
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General description
Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups. Dendrimers are chemically modified by attaching poly ethylene glycol (PEG) molecule to increase its solubility and prolong circulation half-life. “Clickable groups”, such as primary acetylenes, are introduced to the mono dispersed dendritic structures, using “click” chemistry.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Applications of Orthogonal, ?click? Chemistries in the synthesis of functional soft materials
Chemical Reviews, 109 (11), 5620-5686 null
Biocompatible Dendritic Building Blocks for Advanced Biomedical Reasearch
Michael Malkoch and Andreas M Nystrom
Material Matters, 7(3), 47-49 null
Degradable Poly (ethylene glycol) hydrogels for 2 D and 3D cell culture
Andrea M Kasko
Material Matters, 6 (3), 67-75 null
Huiyuan Li et al.
Molecules (Basel, Switzerland), 18(8), 9797-9817 (2013-08-21)
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes
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