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240613

Sigma-Aldrich

2-Chloropropane

≥99%

Synonym(s):

Isopropyl chloride

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About This Item

Linear Formula:
(CH3)2CHCl
CAS Number:
75-29-6
Molecular Weight:
78.54
Beilstein/REAXYS Number:
1730782
EC Number:
200-858-8
MDL number:
MFCD00000867
UNSPSC Code:
12352100
PubChem Substance ID:
24854424
NACRES:
NA.22

vapor pressure

28.11 psi ( 55 °C)
8.59 psi ( 20 °C)

assay

≥99%

form

liquid

refractive index

n20/D 1.378 (lit.)

bp

34-36 °C (lit.)

mp

−118 °C (lit.)

solubility

alcohol: miscible(lit.)
diethyl ether: miscible(lit.)
water: slightly soluble(lit.)

density

0.859 g/mL at 25 °C (lit.)

SMILES string

CC(C)Cl

InChI

1S/C3H7Cl/c1-3(2)4/h3H,1-2H3

InChI key

ULYZAYCEDJDHCC-UHFFFAOYSA-N

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General description

2-Chloropropane decomposes by first-order reaction to give hydrogen chloride and propylene.

Application

2-Chloropropane can be used as a reactant:
  • In the Friedel-Crafts alkylation reaction of difluorobenzene and toluene using solid acid and methylalumoxane catalysts, respectively.
  • To prepare 4-amino-3-iodo-1-(isopropyl)pyrazolo[3,4-d]pyrimidine, a key intermediate for the synthesis of PfPK7 kinase inhibitors.
  • To prepare benzylisopropylphenylphosphine.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

-32.8 °F

flash_point_c

-36 °C

ppe

Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis and resolution of benzylisopropylphenylphosphine, a monodentate P-chiral ligand
Albert J, et al.
Tetrahedron Asymmetry, 11(16), 3335-3343 (2000)
Solid acid catalysts for the efficient synthesis of 2-(2, 4-difluorophenyl) propane
Hu X, et al.
Applied Catalysis A: General, 209(1-2), 117-123 (2001)
MAO-catalyzed Friedel-Crafts reactions of toluene with chloroalkanes and with propylene
Kuwabara J, et al.
J. Mol. Catal. A: Chem., 208(1-2), 39-44 (2004)
Synthesis of 3-(1, 2, 3-triazol-1-yl)-and 3-(1, 2, 3-triazol-4-yl)-substituted pyrazolo [3, 4-d] pyrimidin-4-amines via click chemistry: potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase
Klein M, et al.
Organic & Biomolecular Chemistry, 7(17), 3421-3429 (2009)

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