Skip to Content
MilliporeSigma
All Photos(1)

Documents

191337

Sigma-Aldrich

1-(4-Fluorophenyl)piperazine

98%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H13FN2
CAS Number:
2252-63-3
Molecular Weight:
180.22
EC Number:
218-846-6
MDL number:
MFCD00005960
UNSPSC Code:
12352100
PubChem Substance ID:
24851481
NACRES:
NA.22

assay

98%

form

solid

bp

118-123 °C/0.1 mmHg (lit.)

mp

30-33 °C (lit.)

SMILES string

Fc1ccc(cc1)N2CCNCC2

InChI

1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

InChI key

AVJKDKWRVSSJPK-UHFFFAOYSA-N

Gene Information

rat ... Chrnb2(54239)

Application

1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Craig A Stockmeier et al.
Journal of psychiatric research, 43(10), 887-894 (2009-02-14)
Serotonin-1A receptors may play a role in the pathophysiology of depression and suicide. In postmortem brain tissue, agonist binding to serotonin-1A receptors is reportedly increased or unchanged in depression or suicide, while neuroimaging studies report a decrease in antagonist binding
P E Keane et al.
Neuropharmacology, 21(2), 163-169 (1982-02-01)
Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain
Rapid synthesis of N, N'-disubstituted piperazines. Application to the preparation of No carrier added 1-(4-[18F] fluorophenyl) piperazine and of an [18F]-selective ligand of serotoninergic receptors (5HT2 antagonist).
Collins M, et al.
Journal of the Chemical Society. Perkin Transactions 1, 23, 3185-3188 (1992)
Camilla Montesano et al.
Drug testing and analysis, 9(5), 798-807 (2016-07-28)
In this paper, an analytical method has been developed and validated for the analysis of new psychoactive substances (NPS) and metabolites in hair samples. The method was based on pressurized liquid extraction (PLE) followed by solid-phase extraction (SPE) clean-up and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service