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  • Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.

Immunologic research (2013-04-24)
C A Shaw, L Tomljenovic
ABSTRACT

We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.

MATERIALS
Product Number
Brand
Product Description

Aluminum, IRMM®, certified reference material, 1.0 mm wire
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Sigma-Aldrich
Aluminum, powder, ≥91% (complexometric)
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, granular, <1 mm, 99.7% trace metals basis
Aluminum, wire reel, 5m, diameter 2.0mm, as drawn, 99.999%
Aluminum, wire reel, 5m, diameter 0.25mm, as drawn, 99.999%
Aluminum, wire reel, 50m, diameter 0.25mm, hard, 99.99+%
Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.99+%
Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 13mm, cell wall 0.1mm, core density 0.062g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 2 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 600x600mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 300x300mm, thickness 13.9mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%
Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, insulated wire, 20m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%
Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
Aluminum, tube, 2m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, insulated wire, 2m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, tube, 1000mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%
Aluminum, rod, 200mm, diameter 15.0mm, as drawn, 99.999%
Aluminum, rod, 500mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%