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[Quantitative gas chromatographic determination of pantolactone].

Voprosy meditsinskoi khimii (1984-01-01)
A G Moĭseenok, V S Slyshenkov, E V Sunozova, V A Gurinovich
ABSTRACT

A gas chromatographic procedure is described for quantitative estimation of alpha-hydroxy-beta 1 beta-dimethyl-gamma-butyrolactone (pantolactone). The chromatography was carried out using "LHM-8MD" apparatus equipped with a flame ionization detector. Columns with chromaton N-AW modified by 5% silicone XE-60 were used, helium served as a gas-carrier, chloroform - as a solvent, gamma-butyrolactone was introduced as a standard. High resolving power was achieved in experiments with the column for the analyzed substances and the standard at the sensitivity of the method 7.6 X X 10(-4) mmole/ml.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
D-(−)-Pantolactone, 99%
Sigma-Aldrich
(S)-(+)-Pantolactone, 97%
Sigma-Aldrich
DL-α-Hydroxy-β,β-dimethyl-γ-butyrolactone, purum, ≥97.0% (T)