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  • Comparison of efficacy of three commercially available dentifrices [corrected] on dentinal hypersensitivity: a randomized clinical trial.

Comparison of efficacy of three commercially available dentifrices [corrected] on dentinal hypersensitivity: a randomized clinical trial.

Australian dental journal (2012-11-29)
A R Pradeep, E Agarwal, S B Naik, P Bajaj, N Kalra
ABSTRACT

Dentinal hypersensitivity has been defined as a short, sharp pain arising from exposed dentine as a result of various stimuli such as heat, cold, chemical, or osmotic, that cannot be ascribed to any other pathology. This study was conducted to assess the efficacy of three commercially available toothpastes in the reduction of dentinal hypersensitivity. A total of 149 subjects (72 males and 77 females; aged 20 to 60 years) were entered into the study and randomly divided into four groups: Group 1 - toothpaste containing 5% potassium nitrate; Group 2 - toothpaste containing 5% calcium sodium phosphosilicate with fused silica; Group 3 - toothpaste containing 3.85% amine fluoride; and Group 4 - a placebo toothpaste. After sensitivity scores for controlled air stimulus and cold water at baseline were recorded, subjects were given toothpastes and sensitivity scores were measured again at 2 weeks and 6 weeks. All groups showed a reduction in sensitivity scores at 2 weeks and 6 weeks. The calcium sodium phosphosilicate group was found to be significantly better compared to the other groups at the end of 6 weeks. The calcium sodium phosphosilicate group showed a better reduction in the symptoms of dentinal hypersensitivity.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium nitrate, ACS reagent, ≥99.0%
Sigma-Aldrich
Potassium nitrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99%
Sigma-Aldrich
Potassium nitrate, BioReagent, suitable for cell culture, suitable for plant cell culture
Sigma-Aldrich
Potassium nitrate, BioXtra, ≥99.0%
Sigma-Aldrich
Potassium nitrate, 99.999% trace metals basis
Sigma-Aldrich
Potassium nitrate, 99.99% trace metals basis
Sigma-Aldrich
Potassium nitrate, ReagentPlus®, ≥99.0%
Supelco
Mettler-Toledo Calibration substance ME 51143095, Potassium nitrate, traceable to primary standards (LGC)