SML1148

YIL-781 hydrochloride

≥98% (HPLC)

• Synonym(s): 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
• Empirical Formula (Hill Notation): C₂₄H₂₈FN₃O₂ · xHCl
• CAS Number: 875258-85-8
• Molecular Weight: 409.50 (free base basis)
• MDL number: MFCD19690924
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825682
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: , white to yellow to light brown
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl
• InChI: 1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
• InChI key: QQGRMONBDBMLSP-FERBBOLQSA-N

Description

Application

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.

Biochem/physiol Actions

YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable