Przejdź do zawartości
Merck

Coenzyme Q10 protects hair cells against aminoglycoside.

PloS one (2014-09-30)
Kazuma Sugahara, Yoshinobu Hirose, Takefumi Mikuriya, Makoto Hashimoto, Eiju Kanagawa, Hirotaka Hara, Hiroaki Shimogori, Hiroshi Yamashita
ABSTRAKT

It is well known that the production of free radicals is associated with sensory cell death induced by an aminoglycoside. Many researchers have reported that antioxidant reagents protect sensory cells in the inner ear, and coenzyme Q10 (CoQ10) is an antioxidant that is consumed as a health food in many countries. The purpose of this study was to investigate the role of CoQ10 in mammalian vestibular hair cell death induced by aminoglycoside. Cultured utricles of CBA/CaN mice were divided into three groups (control group, neomycin group, and neomycin + CoQ10 group). In the neomycin group, utricles were cultured with neomycin (1 mM) to induce hair cell death. In the neomycin + CoQ10 group, utricles were cultured with neomycin and water-soluble CoQ10 (30-0.3 µM). Twenty-four hours after exposure to neomycin, the cultured tissues were fixed, and vestibular hair cells were labeled using an anti-calmodulin antibody. Significantly more hair cells survived in the neomycin + CoQ10 group than in the neomycin group. These data indicate that CoQ10 protects sensory hair cells against neomycin-induced death in the mammalian vestibular epithelium; therefore, CoQ10 may be useful as a protective drug in the inner ear.

MATERIAŁY
Numer produktu
Marka
Opis produktu

USP
Ubidecarenone for System Suitability, United States Pharmacopeia (USP) Reference Standard
USP
Ubidecarenone, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Coenzyme Q10, ≥98% (HPLC)
Ubidecarenone for system suitability, European Pharmacopoeia (EP) Reference Standard
Supelco
Coenzyme Q10, analytical standard
Ubidecarenone, European Pharmacopoeia (EP) Reference Standard