Tandem Blaise-alkenylation with unactivated alkynes: one-pot synthesis of alpha-vinylated beta-enaminoesters from nitriles.

The in situ generated Blaise reaction intermediate, a zinc bromide complex of beta-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford alpha-vinylated beta-enaminoesters in good to excellent yields.