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Merck

[3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brain.

European journal of pharmacology (1990-11-27)
S M Tejani-Butt, D J Brunswick, A Frazer
ABSTRAKT

[3H]Nisoxetine binds with high affinity (Kd = 0.7 nM) and selectivity to a homogenous population of sites associated with the uptake of norepinephrine. Specific [3H]nisoxetine binding to rat cortical homogenates was saturable, sodium-dependent and averaged 90% of total binding at its Kd concentration. Pretreatment with the neurotoxin DSP-4 resulted in 95% decrease in binding. [3H]Nisoxetine exhibits superior properties to radioligands previously used and appears to be the radioligand of choice for studies involving uptake sites for norepinephrine.

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Sigma-Aldrich
Nisoxetine hydrochloride, solid, ≥98% (HPLC)