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MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212.

Nature neuroscience (2010-08-17)
Heh-In Im, Jonathan A Hollander, Purva Bali, Paul J Kenny
ABSTRAKT

The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its role in the neurodevelopmental disorder Rett syndrome, is emerging as an important regulator of neuroplasticity in postmitotic neurons. Cocaine addiction is commonly viewed as a disorder of neuroplasticity, but the potential involvement of MeCP2 has not been explored. Here we identify a key role for MeCP2 in the dorsal striatum in the escalating cocaine intake seen in rats with extended access to the drug, a process that mimics the increasingly uncontrolled cocaine use seen in addicted humans. MeCP2 regulates cocaine intake through homeostatic interactions with microRNA-212 (miR-212) to control the effects of cocaine on striatal brain-derived neurotrophic factor (BDNF) levels. These data suggest that homeostatic interactions between MeCP2 and miR-212 in dorsal striatum may be important in regulating vulnerability to cocaine addiction.

MATERIAŁY
Numer produktu
Marka
Opis produktu

Sigma-Aldrich
Anti-MeCP2 Antibody, Upstate®, from rabbit
Sigma-Aldrich
Anti-Brain Derived Neurotrophic Factor Antibody, serum, Chemicon®
Sigma-Aldrich
Anti-BDNF Mouse mAb (35928.11), lyophilized, clone 35928.11, Calbiochem®