T8951

Tangeretin

Name: Tangeretin
Brand: SIGMA
Price: 1000 PLN

≥95% (HPLC)

Synonim(y):

4′,5,6,7,8-Pentamethoxyflavone, 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, NSC 53909, NSC 618905, Ponkanetin

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5 MG

1000,00 zł

10 MG

1960,00 zł

1000,00 zł

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Wzór empiryczny (zapis Hilla):

C₂₀H₂₀O₇

Numer CAS:

481-53-8

Masa cząsteczkowa:

372.37

UNSPSC Code:

12352205

NACRES:

NA.25

PubChem Substance ID:

329826890

EC Number:

207-570-1

Beilstein/REAXYS Number:

351695

MDL number:

MFCD00017438

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Quality Level

100

assay

≥95% (HPLC)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

COc1ccc(cc1)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2

InChI

1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3

InChI key

ULSUXBXHSYSGDT-UHFFFAOYSA-N

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Ta pozycja	PHL89803	HPA073476	52186
Sigma-Aldrich T8951 Tangeretin	PHL89803 Tangeretin	Sigma-Aldrich HPA073476 Anti-EHBP1L1 antibody produced in rabbit	Supelco 52186 (±)-Naringenin
assay ≥95% (HPLC)	assay ≥98.0% (HPLC)	assay -	assay ≥95% (TLC)
application(s) metabolomics vitamins, nutraceuticals, and natural products	application(s) -	application(s) -	application(s) food and beverages
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100

General description

Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.[1][2]

Application

Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae.[3] It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.

Biochem/physiol Actions

Tangeretin displays its anti-cancer effects by modulating different pathways in several cancer types in both in-vitro and in-vivo studies.[1][2] It also exerts antioxidant, anti-inflammatory, and estrogenic properties.[2]

Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Odwiedź Bibliotekę dokumentów

Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation.

Juhee Seo et al.

European journal of pharmacology, 673(1-3), 56-64 (2011-11-02)

Tangeretin, a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities. However, the effect of tangeretin on vascular smooth muscle cells (VSMCs) is unknown. This study examined the effect

Prospects of tangeretin as a modulator of cancer targets/pathways.

Waseem Raza et al.

Pharmacological research, 161, 105202-105202 (2020-09-18)

To date, cancer is the second leading cause of death worldwide after cardiac arrest. A large number of synthetic drugs are available for the treatment of different types of cancer; however, a major problem associated with these drugs is its

Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.

Christophe Tistaert et al.

Analytica chimica acta, 705(1-2), 111-122 (2011-10-04)

Extracts of Citri reticulatae pericarpium (PCR) are commonly used in the Traditional Chinese Medicine. The quality control of PCR is currently performed by single marker analysis, which can hardly describe the complexity of such natural samples. In this study, a

Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K.

Z Cheng et al.

British journal of pharmacology, 162(8), 1781-1791 (2011-01-05)

The mechanisms by which the dietary compound tangeretin has anticancer effects may include acting as a prodrug, forming an antiproliferative product in cancer cells. Here we show that tangeretin also inhibits cell cycle progression in hepatocytes and investigate the role

Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin.

Guy Lewin et al.

Journal of natural products, 73(4), 702-706 (2010-04-02)

Semisynthesis of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (1), a natural flavone that binds with high affinity to tubulin, was performed from hesperidin, the very abundant Citrus flavanone, by a five-step sequence. The last step of the synthesis also gave rise to 5,3'-dihydroxy-3,6,7,4'-tetramethoxyflavone (= casticin

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
T8951-10MG	04061832412092
T8951-5MG	04061837379949

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Tangeretin