SML3044

XL177A

≥98% (HPLC)

• Synonym(s): (S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide, 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-
• Empirical Formula (Hill Notation): C₄₈H₅₇ClN₈O₅
• CAS Number: 2417089-74-6
• Molecular Weight: 861.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1N(CC2(O)CCN(C([C@H](CC3=CC=CC=C3)CCCNC(C4=CC(N=C(CCCC5)C5=C6Cl)=C6C=C4)=O)=O)CC2)C=NC7=CC(NC(CCN8CCN(C)CC8)=O)=CC=C71
• InChI key: UYJWYMWIVMCGQZ-DHUJRADRSA-N

Description

Biochem/physiol Actions

XL177A is a cell penetrant, potent and highly selective covalent inhibitor of the deubiquitinating enzyme USP7 that binds to catalytic cysteine C223.

cell penetrant, potent and highly selective covalent inhibitor of the deubiquitinating enzyme USP7

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable