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SML2406

JI130

≥95% (HPLC)

Synonym(s):

(E)-N-(2-(Allyloxy)phenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$296.00
$251.60

About This Item

Empirical Formula (Hill Notation):
C23H24N2O3
CAS Number:
Molecular Weight:
376.45
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder

$251.60

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assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C

InChI

1S/C23H24N2O3/c1-3-15-28-20-9-5-4-7-17(20)13-14-24-22(26)12-11-18-16-25-23-19(18)8-6-10-21(23)27-2/h3-12,16,25H,1,13-15H2,2H3,(H,24,26)/b12-11+

InChI key

BNTYDBBGNPFECO-VAWYXSNFSA-N

Biochem/physiol Actions

JI130 is a cell penetrant, potent and selective inhibitor of the helix-loop-helix transcription factor Hes1 that blocks Hes1-mediated transcriptional repression. JI130 potently inhibits pancreatic cancer cell lines proliferation, and shrink tumor in a mice pancreatic tumor xenograft model.
cell penetrant, potent and selective inhibitor of the helix-loop-helix transcription factor Hes1 that blocks Hes1-mediated transcriptional repression

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SML0412SML1225SML1679
form

powder

form

powder

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL (clear solution)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

light orange to dark orange

color

white to pink

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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